eISSN: 2345-2781  
Submitted: 26 Aug 2017

Accepted: 23 Sep 2017
First published online: 28 Nov 2017
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J Renal Inj Prev. 2018;7(1):7-10.
doi: 10.15171/jrip.2018.02

Scopus id: 85042592286

Mini-Review

Metformin; a mini-review to its antioxidative and anti-inflammatory properties

Abolfazl Abbaszadeh 1, Sahar Koushki 2, Shirin Koushki 2, Marzieh Eskandarzadeh 2, Amin Hasanvand 3 *

1 Department of Surgery, Lorestan University of Medical Sciences, Khorramabad, Iran
2 Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran
3 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran
*Corresponding author: Amin Hasanvand, Ph.D.; Email: dr.hasanvand@yahoo.com

Abstract

Metformin, a hypoglycemic drug, increases peripheral glucose uptake, decreases liver glucose production and suppresses insulin resistance in liver and skeletal muscle. The molecular anti-inflammatory mechanism of metformin involves the reduction of the level of proinflammatory cytokines through AMPK activation. It can reduce endothelial dysfunction by ameliorating the expression of inflammatory gene and protein like vascular cell adhesion molecule-1 (VCAM-1), and vasodilating maternal vessels. Many studies showed that AMPK activation were the main contributors to the antioxidant and anti-inflammatory effects of metformin.

Implication for health policy/practice/research/medical education:

Metformin can improve chronic inflammation and oxidative stress. The main mechanism of AMPK effects was decrease of proinflammatory cytokines and oxidative stress factors after treatment with metformin in diseases.

Please cite this paper as: Abbaszadeh A, Koushki S, Koushki S, Eskandarzadeh M, Hasanvand A. . Metformin; a mini-review to its antioxidative and anti-inflammatory properties. J Renal Inj Prev. 2018;7(1):7-10. DOI: 10.15171/jrip.2018.02.

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