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Submitted: 29 Dec 2021
Accepted: 30 Jan 2022
ePublished: 01 Feb 2022
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J Renal Inj Prev. 2023;12(4): e32005.
doi: 10.34172/jrip.2022.32005

Scopus ID: 85174675363
  Abstract View: 795
  PDF Download: 177

Original

Factors related to mortality in hemodialysis patients with COVID-19

Gulay Yilmaz 1* ORCID logo, Ozge Timur 2 ORCID logo

1 Ac─▒badem International Hospital, Department of Nephrology and Transplantation, Istanbul, Turkey
2 Erzurum Regional Research and Training Hospital, Department of Internal Medicine, Erzurum, Turkey
*Corresponding Author: Gulay Yilmaz, Email: drgulaytastan@hotmail.com

Abstract

Introduction: The mortality rate in COVID-19 patients is about 2%, however advanced age, male gender, comorbid diseases increase the risk of mortality. Patients with end-stage renal disease (ESRD) and hemodialysis (HD) treatment are more susceptible to infection due to both existing comorbid diseases and immune suppression caused by uremia.

Objectives: This study aims to show the potential of easily obtainable, inexpensive and reproducible markers in predicting mortality in HD patients at the time of diagnosis.

Patients and Methods: In this study, we examined the relationship between; neutrophil to lymphocyte ratio (NLR), mean platelet volume (MPV) and C-reactive protein (CRP)/albumin values at the time of hospital admission with mortality in 75 HD patients diagnosed with COVID-19. All analyses were conducted using IBM SPSS Statistics 21.0 and MS-Excel 2010 software.

Results: A total of 75 HD patients diagnosed with COVID-19 were included in the study. Out of these, at least 19 (25.3%) patients received hydroxychloroquine, 68 (90.6%) patients favipiravir, two (2.6%) patients tocilizumab and two patients (2.6%) immune plasma therapy. Among these patients, sixteen patients (21.3%) needed invasive mechanic ventilation, eight patients (10.6%) needed high flow oxygen and seven patients (9.3%) needed non-invasive mechanic ventilation and 17 of 75 patients (23%) died. A total of 14 of the 17 non-survivors were intubated. In comparison between survivors and non-survivors in our study; NLR, MPV, CRP, CRP/albumin and phosphorus values were significantly higher in the non-survivors group.

Conclusion: According to this study, NLR, MPV and CRP/albumin values are associated with mortality in HD patients affected with COVID-19.


Implication for health policy/practice/research/medical education:

COVID-19 positive hemodialysis patients have increased mortality risk. This study aims to show the potential of easily obtainable, inexpensive and reproducible markers in predicting mortality in hemodialysis patients at the time of diagnosis. In this study, NLR, MPV and CRP/albumin values are associated with mortality in HD patients affected with COVID-19.

Please cite this paper as: Yilmaz G, Timur O. Factors related to mortality in hemodialysis patients with COVID-19. J Renal Inj Prev. 2023; 12(4): e32005. doi: 10.34172/jrip.2022.32005.

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