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Submitted: 11 Nov 2023
Accepted: 22 Dec 2023
ePublished: 11 Jan 2024
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J Renal Inj Prev. 2024;13(2): e32267.
doi: 10.34172/jrip.2024.32267
  Abstract View: 172
  PDF Download: 57

Mini-Review

Renal involvement in Takayasu’s arteritis; a mini-review study

Mansour Salesi 1, Sarah Hosseinpoor 2* ORCID logo

1 Department of Rheumatology, Isfahan University of Medical Sciences, Isfahan, Iran
2 Isfahan University of Medical Sciences, Isfahan, Iran
*Corresponding Author: Sarah Hosseinpoor, Email: sarahhosseinpoor68@gmail.com

Abstract

Takayasu’s arteritis is a chronic inflammatory disease affecting the aorta and its branches. It can also involve other organs, such as the kidneys. Inflammation of the renal artery can lead to hypertension, proteinuria, and progressive loss of kidney function over time. This condition is known as renovascular hypertension. The treatment for Takayasu’s arteritis involves managing symptoms with medications like corticosteroids, immunosuppressants, and antihypertensive drugs. Surgical intervention may be necessary if there are complications, such as aneurysms or blockages in the affected blood vessels. Lifestyle modifications such as maintaining a healthy weight, regular exercise, and smoking cessation can also help manage better disease management.

Implication for health policy/practice/research/medical education:

Takayasu’s arteritis, also known as Takayasu’s disease, is a rare chronic inflammatory disease that primarily affects the large blood vessels, especially the aorta and its branches. Although the disease primarily affects the arteries, it can also involve other organs, including the kidneys. Dysregulation of T cells, particularly CD4+ and CD8+ T cells, is thought to play a significant role in developing vascular inflammation. The imbalance of pro-inflammatory and anti-inflammatory cytokines, such as interferon-gamma and IL-6, also contributes to renal involvement in this disease. Furthermore, individuals with Takayasu’s arteritis should regularly monitor kidney function, including blood pressure checks, urine tests, and kidney function tests such as serum creatinine and estimated glomerular filtration rate. Early detection and effective management of kidney involvement prevent or minimize the complications. Consulting with a healthcare professional, such as a rheumatologist or nephrologist, is crucial for proper evaluation and treatment.

Please cite this paper as: Salesi M, Hosseinpoor S. Renal involvement in Takayasu’s arteritis; a mini-review study. J Renal Inj Prev. 2024; 13(2): e32267. doi: 10.34172/jrip.2024.32267.

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