Abolfazl Abdollahpour
1, Hoda Doustmohammadi
2, Leila Sadeghi
3, Babak Hosseinzadeh Zoroufchi
1*1 Department of Anesthesiology, Kowsar Hospital, Semnan University of Medical Sciences, Semnan, Iran 2
2 Department of Anatomy, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran
3 Center of obstetrics and Gynecology, Shahid Mahallati Hospital, Tabriz, Iran
Abstract
Acute renal failure (ARF) is a major medical problem during pregnancy with maternal and
fetal outcomes. While the trend of pregnancy-related ARF is on a decline due to the advances in
obstetrics care and the legality of abortion among developed countries, this situation remains
one of the serious health problems in the developing nations. This review aims to evaluate
the current studies with regards to pregnancy related ARF pathophysiology, risk factors and
treatment. PubMed, Embase, Scopus and directory of open access journals (DOAJ) databases
were searched to obtain the information. Most of the studies in this review were conducted in
observational, both prospective and retrospective studies. Results demonstrated a variety of
major pregnancy-related ARF causes including obstetric hemorrhage, hypertensive disorders
in pregnancy, sepsis, thrombotic microangiopathy and acute fatty liver in pregnancy.
Aside from awareness of the pathogenesis of pregnancy-related ARF and its risk factors,
understanding the physiological renal adaptation during pregnancy is essential for early
detection, diagnosis, and proper management to prevent the pregnancy related complications.
Implication for health policy/practice/research/medical education:
Obstetric acute renal failure (ARF) is a serious condition which can occur in different phases of pregnancy. Its materno-fetal
outcomes hence remain as a critical pregnancy-related complication in both developed and developing countries.
Please cite this paper as: Abdollahpour A, Doustmohammadi H, Sadeghi L, Hosseinzadeh Zoroufchi B. Acute renal
failure during the pregnancy: a review on pathophysiology, risk factors and management. J Renal Inj Prev. 2018;7(4):314-320.
DOI: 10.15171/jrip.2018.68.