Nickan Research Institute Journal of Renal Injury Prevention 2345-2781 7 1 2018 03 01 Serum creatinine levels in relationship with mean platelet volume in patients with chronic kidney disease 38 41 10.15171/jrip.2018.09 EN Mohammad Reza Tamadon Sayed Mohammad-Ali Torabi Jamileh Moghimi Majid Mirmohammadkhani Farahnaz Ghahremanfard Journal Article 10.15171/jrip.2018.09 2017 05 20 2017 08 14 Introduction: Chronic kidney disease (CKD) is a progressive decline in glomerular filtration rate (GFR) which is mainly caused by diabetic nephropathy and hypertension. Objectives: This study evaluated the relationship between changes in mean platelet volume (MPV) and serum creatinine levels. Patients and Methods: In this retrospective study, medical records of 100 patients with CKD including demographics data, medications, past-history, serum creatinine levels, and MPV were gathered. Additionally, we excluded patients who had a history of taking aspirin, idiopathic thrombocytopenic purpura, preeclampsia, sepsis, disseminated intravascular coagulation, aplastic anemia and administration of cytotoxic drugs. Results: This study was conducted on 100 CKD patients. Relationship between changes in MPV with serum creatinine level was evaluated by adjusting for gender, age, CKD stages, etiology, and weight. The changes in MPV and serum creatinine level were not significant with adjusting by underlying variables. However, in patients with high blood pressure, relationship of serum creatinine levels with MPV was inversely significant (r = -0.484, P =0.049). Conclusion: In CKD patients with high blood pressure, the changes in serum creatinine level have an inverse relationship with MPV. However, MPV is not an appropriate indicator for predicting of creatinine changes.