Nickan Research Institute Journal of Renal Injury Prevention 2345-2781 8 4 2019 12 01 Prevention of kidney injury after myocardial ischemia reperfusion is achievable with short-term protein restriction 301 305 10.15171/jrip.2019.55 EN Baran Hashemi https://orcid.org/0000-0001-9311-5365 Majid Maleki Amir Darbandi Azar Morteza Zare Seyed Mohammad Mazloomi https://orcid.org/0000-0003-0887-2375 Nasim Naderi Journal Article 10.15171/jrip.2019.55 2019 06 14 2019 08 30 Introduction: Kidney injury is a serious complication after cardiovascular surgery. Left ventricular dysfunction, pre-operative kidney dysfunction and inflammation can predict kidney injury after myocardial reperfusion. Objectives: We aimed to study whether short-term protein restriction (PR) would influence blood urea nitrogen (BUN) levels after myocardial reperfusion injury. Materials and Methods: Male Wistar rats fed with either AIN-93M or AIN-93M protein restricted diet one week before myocardial reperfusion injury. After surgery, feeding continued with AIN-93M for 1 week. Results: BUN levels increased significantly compared to the pre-operative level in the control group (P=0.03) and decreased significantly in the protein-restricted group (P=0.01). Multivariate analysis showed that PR through its effect on blood glucose (β=1.2, 95% CI=0.1- 2.34), IL-6 (β=-2.22, 95% CI=-3.9–-0.54) and left ventricular ejection fraction (LVEF) (β=-1.21, 95% CI=-2.34- 0.09) was able to protect the kidney from myocardial reperfusion. Conclusion: Short-term PR through modulating pre-operative IL-6, post-operative blood glucose levels and LVEF could prevent kidney injury after myocardial reperfusion injury.