ePublished: 10 Oct 2013
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J Renal Inj Prev. 2013;2(4): 133-137.
doi: 10.12861/jrip.2013.43
PMID: 25340152
PMCID: PMC4206030
  Abstract View: 1735
  PDF Download: 988

Original Article

Pattern of biopsy proven renal diseases at PNS SHIFA, Karachi: A cross-sectional survey

Sohail Sabir 1 * , Muhammed Mubarak 1, Irfan Ul-Haq 1, Aisha Bibi 1

1 Departments of Nephrology1and Histopathology2, PNS Shifa and SIUT, Karachi, Pakistan
*Corresponding author: Sohail Sabir , Department of Nephrology, PNS SHIFA, Karachi, Pakistan. drsohailsa@hotmil.com


Introduction: Percutaneous renal biopsy (RB) is an invaluable diagnostic procedure in patients with medical renal diseases.Objectives: To determine the pattern of biopsy proven renal disease (BPRD) from a tertiary care naval hospital in Karachi, Pakistan.Methods and Materials: All the renal biopsies in adult patients (≥18 years) performed at our hospital from 2008 to 2012 were retrospectively reviewed. The biopsies were evaluated by light microscopy and immunofluorescence.Results: A total 60 cases were analyzed. The mean age was 33.3±12.9 years (range: 18 to 72 years).The male to female ratio was 3:1. The most common indication of renal biopsy was nephrotic syndrome (43.3%), followed by renal failure (26.6%) and non-nephrotic proteinuria (23.3%). Primary glomerulonephritides (PGN) were predominant overall lesions, found in 46 (76.6%) of the total biopsies. Among PGN, the most common lesion was focal segmental glomerulosclerosis (FSGS), followed by membranous glomerulonephritis (MGN), IgA nephropathy (IgAN) and chronic sclerosing glomerulonephritis (CSGN) and a variety of rare lesions. Secondary glomerulonephritides (SGN) were found in only three (5%) cases. There were two cases of amyloidosis and one of lupus nephritis (LN). Tubulointerstitial disease (TID) and vascular disease were rare.Conclusion: This study provides information about the epidemiology of BPRD in a large tertiary care naval center in Southern Pakistan.
Keywords: Epidemiology, Renal biopsy, Glomerulonephritis, Nephropathy
Implication for health policy/practice/research/medical education: Retrospective reviews and analysis of renal biopsies serve a useful function in understanding the epidemiology of medical renal diseases in an area. Although, inherently biased and heavily dependant on biopsy policies, these studies do shed some light on the prevalent renal diseases in a community or region. This study represents such an attempt of determining the most common medical renal diseases in adults from this part of the world.

Please cite this paper as: Sabir S, Mubarak M, Ul-Haq I, Bibi A. Pattern of biopsy proven renal diseases at PNS SHIFA, Karachi: A cross-sectional survey. J Ren Inj Prev 2013; 2(4): 133-137. DOI: 10.12861/jrip.2013.43
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