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Submitted: 07 Sep 2020
Accepted: 25 Oct 2020
ePublished: 26 Nov 2020
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J Renal Inj Prev. 2021;10(1): e08.
doi: 10.34172/jrip.2021.08
  Abstract View: 179
  PDF Download: 117

Review

COVID-19 and the kidney; mechanisms of tubular injury by SARS-CoV-2

Rojin Chegini 1 ORCID logo, Zahra Mojtahedi 2 ORCID logo, Bhaskar VKS Lakkakula 3 ORCID logo, Aiyoub Pezeshgi 4 * ORCID logo, Saniya Niazi 5 ORCID logo, Hamid Nasri 6,7

1 Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Health Care Administration and Policy, School of Public Health, University of Nevada, Las Vegas, Las Vegas, Nevada, USA
3 Department of Zoology, Guru Ghasidas Vishwavidyalaya, Bilaspur, India
4 Department of Internal Medicine and Zanjan Metabolic Disease Research Center, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
5 Comprehensive Hematology Oncology LLC. 5000 Park St N # 1017, St. Petersburg, Fl, USA
6 Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
7 Nickan Research Institute, Isfahan, Iran
*Corresponding author: Aiyoub Pezeshgi, Email: Dr.a.pezeshki@gmail.com

Abstract

Coronavirus disease 2019 (COVID-19) is an ongoing pandemic, reported to cause asymptomatic to severe disease and eventually death. Multi-organ failure and death in patients with severe COVID-19 is associated with increased release of pro-inflammatory cytokines into the blood stream. Renal impairment is reported in a significant proportion of COVID-19 patients and is associated with high mortality. Acute kidney injury (AKI) is multifactorial and involving overlapping pathogenic mechanisms. This review updates the reader of recent publications dealing with the mechanisms underlying AKI in patients with COVID-19. A full understanding of all the possible ways in which the system plays its role in AKI is still a matter of research. Further studies are warranted to better understand the causes of AKI in COVID-19 patients.
Keywords: Chronic kidney disease, COVID-19, Acute respiratory distress syndrome, SARS-CoV-2, Angiotensin-converting enzyme II, Hemodialysis, Acute renal failure, End-stage renal disease, Acute kidney injury

Implication for health policy/practice/research/medical education:

Acute kidney injury (AKI) is more common in severely ill patients with COVID-19. AKI is strongly correlated with the occurrence of respiratory failure disease severity. Acute kidney injury in COVID-19 patients conferred a poor prognosis and outcomes.

Please cite this paper as: Chegini R, Mojtahedi Z, Lakkakula BVKS, Pezeshgi A, Niazi S, Nasri H. COVID-19 and the kidney; mechanisms of tubular injury by SARS-CoV-2. J Renal Inj Prev. 2021; 10(1): e08. doi: 10.34172/jrip.2021.08.

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